{"id":41997,"date":"2024-01-16T13:49:05","date_gmt":"2024-01-16T12:49:05","guid":{"rendered":"https:\/\/mag.komk.fr\/?p=41997"},"modified":"2024-01-16T13:49:12","modified_gmt":"2024-01-16T12:49:12","slug":"nez-x-gdr-o3-the-structure-of-olfactory-receptors-laid-bare","status":"publish","type":"post","link":"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nez-x-gdr-o3-the-structure-of-olfactory-receptors-laid-bare\/","title":{"rendered":"Nez x GDR O3 \u2013 The structure of olfactory receptors laid bare"},"content":{"rendered":"    <div id=\"chapo-block_62d0b6ace36ec619625f3ea1db0272d5\" class=\"chapo\">\r\n        <blockquote class=\"chapo-blockquote\">\r\n            <span class=\"chapo-text\"><p>We recently announced the launch of <a href=\"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nathalie-mandairon-various-unique-projects-have-been-launched-thanks-to-gdr-o3\/\">a partnership between GDR O3 and Nez<\/a>. It gives us the perfect opportunity to offer you a regular round-up of the studies resulting from the work undertaken by the research group and its team of scientists from every field with a common focus: odour in all its forms.<br \/>\nThe idea? Nez reads the scientific publications, and offers you a simpler, more accessible but still precise version.<br \/>\nToday, let&#8217;s take a look through the microscope at olfactory receptors, these essential yet little-known proteins, with Claire de March, Assistant Professor at CNRS &#8211; Universit\u00e9 Paris-Saclay and member of the GDR O3.<\/p>\n<\/span>\r\n        <\/blockquote>\r\n        <style type=\"text\/css\">\r\n            #chapo-block_62d0b6ace36ec619625f3ea1db0272d5 {\r\n                background: ;\r\n                color: ;\r\n            }\r\n        <\/style>\r\n    <\/div>\r\n    \n\n\n<p><a href=\"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nez-x-gdr-o3-cracking-the-combinatorial-odour-code\/\" target=\"_blank\" rel=\"noreferrer noopener\">Artificial intelligence is not the only approach to offer greater insights into how our sense of smell works<\/a>. The challenge is that odorant receptors are particularly wary of revealing themselves in the laboratory, making it difficult to understand their structure: \u201cPreparing receptors for laboratory study remains tricky because they present very poor expression on the surface of cell models commonly used for protein production,\u201d explains biochemist Claire de March. Working with an international team of scientists, she participated in the creation of an experimental process that enables the production of a human odorant receptor in the laboratory and determination of its structure using cryo-electron microscopy. This technique involves rapidly freezing a sample and taking a snapshot of the protein to observe it in its native state. The receptor in question is OR51E2, found in the nose and in prostate cancer cells; it was judged to be the most suitable candidate because of its stability. Unlike many others, OR51E2 \u201chas remained stable as species have evolved,\u201d notes Claire de March.<\/p>\n\n\n\n<p>What does the structure of this first odorant receptor look like? It \u201cdisplays distinctive molecular structural patterns that may have a specific link to olfaction,\u201d enabling us to smell, for instance, the scent of cheese. The research represents a real step forwards in understanding these proteins, earning it <a href=\"https:\/\/www.nature.com\/articles\/s41586-023-05798-y\" target=\"_blank\" rel=\"noreferrer noopener\">an article in the prestigious journal <em>Nature<\/em><\/a>.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Contact: claire.de-march@cnrs.fr&nbsp;<\/li>\n\n\n\n<li>More about GDR O3 on its website: https:\/\/www.gdr-o3.cnrs.fr\/<\/li>\n\n\n\n<li>Claire de March, winner of the 2023 Ir\u00e8ne Joliot-Curie &#8220;Young Women in Science&#8221; prize, is one of the icons from <em><a href=\"https:\/\/shop.bynez.com\/boutique\/nez-the-olfactory-magazine\/fashion-perfume\/\">Nez#16 &#8211; Fashion &amp; Perfume<\/a><\/em><\/li>\n<\/ul>\n\n\n\n<p><em>Main visual: \u00a9\u00a0Ad\u00e8le Ch\u00e9vara<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Olfactory receptors are mysterious, but they are gradually unveiling their secrets to researchers. Biochemist Claire de March, a member of the GDR O3, and her colleagues were recently able to observe this secretive protein, in order to understand it better.<\/p>\n","protected":false},"author":12139,"featured_media":41993,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","footnotes":""},"categories":[677,7500,1415,1418],"tags":[7515,7414,986,5960],"coauthors":[2930],"class_list":["post-41997","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-nez-x-gdr-o3-en","category-olfactory-culture","category-science-en","tag-claire-de-march-en","tag-cnrs-en","tag-sense-of-smell","tag-non-classifiee-en-12","pmpro-has-access"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nez x GDR O3 \u2013 The structure of olfactory receptors laid bare - Nez the olfactory cultural movement<\/title>\n<meta name=\"description\" content=\"Olfactory receptors are mysterious, but they are gradually unveiling their secrets to researchers. Biochemist Claire de March, a member of the GDR O3, and her colleagues were recently able to observe this secretive protein, in order to understand it better.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nez x GDR O3 \u2013 The structure of olfactory receptors laid bare - Nez the olfactory cultural movement\" \/>\n<meta property=\"og:description\" content=\"Olfactory receptors are mysterious, but they are gradually unveiling their secrets to researchers. Biochemist Claire de March, a member of the GDR O3, and her colleagues were recently able to observe this secretive protein, in order to understand it better.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nez-x-gdr-o3-the-structure-of-olfactory-receptors-laid-bare\/\" \/>\n<meta property=\"og:site_name\" content=\"Nez\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/nezlarevue\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-16T12:49:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-16T12:49:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mag.komk.fr\/wp-content\/uploads\/2024\/01\/GDRO3_2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Jessica Mignot\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica Mignot\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nez-x-gdr-o3-the-structure-of-olfactory-receptors-laid-bare\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nez-x-gdr-o3-the-structure-of-olfactory-receptors-laid-bare\/\"},\"author\":{\"name\":\"Jessica Mignot\",\"@id\":\"https:\/\/mag.komk.fr\/en\/#\/schema\/person\/a688ef77e58c5825844c1006861cbbae\"},\"headline\":\"Nez x GDR O3 \u2013 The structure of olfactory receptors laid bare\",\"datePublished\":\"2024-01-16T12:49:05+00:00\",\"dateModified\":\"2024-01-16T12:49:12+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nez-x-gdr-o3-the-structure-of-olfactory-receptors-laid-bare\/\"},\"wordCount\":286,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/mag.komk.fr\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nez-x-gdr-o3-the-structure-of-olfactory-receptors-laid-bare\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/mag.komk.fr\/wp-content\/uploads\/2024\/01\/GDRO3_2.jpg\",\"keywords\":[\"Claire de March\",\"CNRS\",\"Sense of smell\",\"Smell\"],\"articleSection\":[\"News\",\"Nez x GDR O3\",\"Olfactory Culture\",\"Science\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nez-x-gdr-o3-the-structure-of-olfactory-receptors-laid-bare\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nez-x-gdr-o3-the-structure-of-olfactory-receptors-laid-bare\/\",\"url\":\"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nez-x-gdr-o3-the-structure-of-olfactory-receptors-laid-bare\/\",\"name\":\"Nez x GDR O3 \u2013 The structure of olfactory receptors laid bare - Nez the olfactory cultural movement\",\"isPartOf\":{\"@id\":\"https:\/\/mag.komk.fr\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nez-x-gdr-o3-the-structure-of-olfactory-receptors-laid-bare\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/mag.komk.fr\/en\/nez-x-gdr-o3-en\/nez-x-gdr-o3-the-structure-of-olfactory-receptors-laid-bare\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/mag.komk.fr\/wp-content\/uploads\/2024\/01\/GDRO3_2.jpg\",\"datePublished\":\"2024-01-16T12:49:05+00:00\",\"dateModified\":\"2024-01-16T12:49:12+00:00\",\"description\":\"Olfactory receptors are mysterious, but they are gradually unveiling their secrets to researchers. 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